| Candidate | Party | Last position in government | Relatives in government | Elected |
|---|
| Ina Ambolodto | Liberal | DILG Assistant Secretary for Muslim Affairs and Special Concerns and former Maguindanao officer-in-charge | none | |
| Leila de Lima | Liberal | former Secretary of Justice (–) | none | |
| Franklin Drilon | Liberal | Senate President of the Philippines (–present, –, ) Senator of the Philippines (–present, –) Majority leader of the Senate of the Philippines (–) Executive Secretary (–) Secretary of Justice (–, –) Secretary of Labor and Employment (–) | none | |
| TG Guingona | Liberal | former Member of the Philippine House of Representatives from Bukidnon's Second District (–) | Teofisto Guingona, Jr. (father) Ruth de Lara Guingona (mother) Teofisto Guingona, Sr. (grandfather) | |
| Risa Hontiveros | Akbayan | board director of the Philippine Health Insurance Corporation (), former Member of the Philippine House of Representatives from Akbayan Partylist (–) | none | |
| Panfilo Lacson | Independent | former Presidential Assistant for Rehabilitation and Recovery (–) former Senator of the Philippines (–), former Chief of the Philippine National Police (–) | none | |
| Mark Lapid | Aksyon | chief operating officer of the Tourism Infrastructure and Enterprise Zone Authority (–), former Governor of Pampanga (–) | Lito Lapid (father) | |
| Cresente Paez | Independent | Coop-NATCCO Party-list Representative (–present, –), Partylist Coalition Foundation Chairman | none | |
| Francis Pangilinan | Liberal | former Presidential Assistant for Food Security and Agricultural Modernization (–), Senator of the Philippines (–), former Councilor of Quezon City (–) | none | |
| Jericho Petilla | Liberal | former Secretary of the Department of Energy (–), former Governor of Leyte (–) | Leopoldo E. Petilla (father), Remedios Matin Petilla (mother), Leopoldo Dominico Petilla (brother) | |
| Ralph Recto | Liberal | Senator of the Philippines (–present, –) former Director-General of the National Economic and Development Authority (–), former Batangas' 4th district Representative (–) | Vilma Santos (wife), Ricky Recto (brother) Rafael Recto (father), Claro M. Recto (grandfather) | |
| Joel Villanueva | Liberal | former Technical Education and Skills Development Authority Director General (–), former Member of the Philippine House of Representatives from CIBAC Partylist (–) | Eduardo "Jon-Jon" Villanueva (brother) | |